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Bioactive PdPt nanosheets for hypoxia modulation-enhanced radiotherapy
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DOI：10.1016/j.nantod.2026.103129.png)
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Abstract
En 中文
• BSA-modified PdPt nanosheets enabled X-ray/NIR combination therapy. • PdPt@BSA relieved tumor hypoxia through catalytic O2 generation. • Combined therapy enhanced ROS production and DNA damage in tumor cells. • PdPt@BSA induced ICD and activated the cGAS–STING pathway. • The nanoplatform achieved potent antitumor efficacy with good biosafety.
Keywords:
PdPt nanosheets
Radiosensitization
Photothermal–radiotherapy
Hypoxia modulation
Immunogenic cell death
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