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Bioartificial livers (BAL):: current technological aspects and future developments

delete2001-01-01
delete57
PRE
AI
C
Cécile Legallais *
B
Bertrand David
E
Emmanuel Doré
DOI：10.1016/S0376-7388(00)00539-1delete
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Abstract

Abstract

En 中文
Several attempts have been made to develop bioartificial support for the treatment of patients with acute or fulminant liver failure. In this paper, the authors have reviewed the technological aspects of the previously developed bioreactor devices like membrane-based devices, direct perfusion systems and entrapment-based columns. For each type, the technological requirements were first theoretically addressed and then confronted with the actual bioreactor configurations. A new bioreactor design has been proposed to enhance the performance of a bioartificial liver consisting of porcine hepatocytes entrapped in alginate beads. Finally, perspectives were drawn for the next developments of such promising bioartificial organs. (C) 2001 Elsevier Science B.V. All rights reserved.
Keywords:
hepatocyte
bioreactor
hollow fiber
encapsulation
fluidized bed
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Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Journal of Membrane Science cover
Journal of Membrane Science
IF:
9
Papers:
2.1W
Citations:
9.4W

Organization

No organization information available