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Biochemical basis for pharmacological intervention as a reprogramming strategy against hypertension and kidney disease of developmental origin
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DOI：10.1016/j.bcp.2018.01.014.png)
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Abstract
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The concept of developmental origins of health and disease (DOHaD) stipulates that both hypertension and kidney disease may take origin from early-life insults. The DOHaD concept also offers reprogramming strategies aiming at shifting therapeutic interventions from adulthood to early life, even before clinical symptoms are evident. Based on those two concepts, this review will present the evidence for the existence of, and the programming mechanisms in, kidney developmental programming that may lead to hypertension and kidney disease. This will be followed by potential pharmacological interventions that may serve as a reprogramming strategy to counter the rising epidemic of hypertension and kidney disease. We point out that before patients could benefit from this strategy, the most pressing issue is for the growing body of evidence from animal studies in support of pharmacological intervention as a reprogramming strategy to long-term protect against hypertension and kidney disease of developmental origins to be validated clinically and the critical window, drug dose, dosing regimen, and therapeutic duration identified. (C) 2018 Elsevier Inc. All rights reserved.
Keywords:
Developmental origins of health and disease (DOHaD)
Reprogramming
Hypertension
Chronic kidney disease
Nephron endowment
Oxidative stress
Renin-angiotensin system
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