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Biocompatible Hydrogenated Graphene Interfaces Promote Axonal Regeneration
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DOI：10.1002/sstr.70536.png)
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Abstract
En 中文
Neuroregeneration refers to the regrowth and functional reconnection of neural cells and their associated structures following damage caused by neurodegenerative diseases or mechanical injuries. Recent advances in nanotechnology, particularly the development of nanomaterials, have significantly expanded the toolkit for promoting neural repair. Two-dimensional (2D) materials have garnered special interest in biomedical applications because of their unique properties and potential for tailoring the physiological interactions with organic matter. Graphene and functionalized forms of graphene are examples of 2D materials whose characteristics make them attractive candidates for neural interfaces. Here, we evaluate the ability of pristine monolayer graphene (Gr) grown via chemical vapor deposition and Gr subjected to chemical surface modification (hydrogenated graphene, HGr) to help the recovery after a neuronal lesion with minimal astroglia activation. Both substrates showed good biocompatibility and the absence of activation of inflammatory responses by primary glial cells. Our data show that the neuronal regrowth and reconnection in vitro after mechanical lesion are enhanced on HGr, while they are nearly absent on Gr. These observations underscore the importance of the atomic composition of surfaces in contact with the brain environment and support the potential of HGr as a platform for advanced manipulation of neuronal behavior following injury.
Keywords:
graphene
neural interfaces
neuroimmune activation
neuronal regeneration
regenerative medicine
surface hydrogenation
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