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Bioinspired Bottlebrush Polymers Effectively Alleviate Frictional Damage Both In Vitro and In Vivo
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DOI：10.1002/adma.202401689.png)
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Abstract
En 中文
Bottlebrush polymers (BB) have emerged as compelling candidates for biosystems to face tribological challenges, including friction and wear. This study provides a comprehensive assessment of an engineered triblock BB polymer's affinity, cell toxicity, lubrication, and wear protection in both in vitro and in vivo settings, focusing on applications for conditions like osteoarthritis and dry eye syndrome. Results show that the designed polymer rapidly adheres to various surfaces (e.g., cartilage, eye, and contact lens), forming a robust, biocompatible layer for surface lubrication and protection. The tribological performance and biocompatibility are further enhanced in the presence of hyaluronic acid (HA) both in vitro and in vivo. The exceptional lubrication performance and favorable interaction with HA position the synthesized triblock polymer as a promising candidate for innovative treatments addressing deficiencies in bio-lubricant systems. The biocompatible bottlebrush polymer (BB) can rapidly adhere to various substrates, offering exceptional antifouling and lubricant properties. It holds promise for treating diseases linked to bio-lubricant systems and optimizing the performance of medical devices, including contact lenses. image
Keywords:
bio-lubrication
bottlebrush
contact lens
dry eye
osteoarthritis
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