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Biomarker value of plasma endothelial microvesicle-derived circRNA 0006222 in vascular ageing and carotid atherosclerosis
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DOI：10.3389/fnins.2026.1872315.png)
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Abstract
En 中文
BackgroundEndothelial microvesicles (EMVs) carrying circular RNAs (circRNAs) have emerged as promising novel biomarkers of ageing-associated disorders. This study investigated the potential of plasma EMVs-circ_0006222 as vascular ageing (VA) and carotid atherosclerosis (CAS) biomarkers.MethodsA circRNA microarray was applied to screen for differentially expressed circRNAs in plasma EMVs obtained from CAS participants; VA participants and healthy controls. VA was assessed according to intima thickness; and CAS was evaluated by using computed tomography angiography. The plasma EMVs-circ_0006222 level was determined via qRT-PCR. EMVs-circ_0006222 levels in patients of different ages and with different severities of CAS were compared. The diagnostic potential of EMVs-circ_0006222 was evaluated by using multivariable logistic regression and receiver-operator characteristic (ROC) curve analyses.ResultsA total of 47 healthy controls; 81 VA participants and 216 CAS participants were included in this study. Plasma EMVs-circ_0006222 levels were observed to be negatively associated with age. The plasma level of EMVs-circ_0006222 was markedly reduced in elderly participants; as well as VA and CAS participants; moreover; the decrease was most evident in the CAS group. The plasma EMVs-circ_0006222 level was declined in the severe CAS compared with the mild and moderate CAS subjects. Plasma EMVs-circ_0006222 level was identified by multivariate logistic regression as a significant; independent risk factor for VA and CAS. The areas under the ROC curve of plasma EMVs-circ_0006222 for diagnosing VA and CAS were 0.628 and 0.773; respectively.ConclusionPlasma EMVs-circ_0006222 may serve as a promising biomarker for VA and CAS.
Keywords:
biomarker
carotid atherosclerosis
vascular ageing
circular RNAs 0006222
endothelial microvesicles
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