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Biomarkers of Pre-COPD Lung Function Trajectories in Middle Age: A Prospective Study From 1st to 6th Decade

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OA
AI
D
Dinh Bui
D
Don Vicendese
J
Jonathan Pham
N
Nur Sabrina Idrose
A
Adrian Lowe
C
Caroline Lodge
R
Raisa Cassim
C
Chamara Senaratna
G
Gayan Bowatte
G
Garun Hamilton
A
Alan James
P
Paul Thomas
R
R Wood-Baker
P
Peter Frith
G
Gary Anderson
P
Philip M. Hansbro
G
Graeme Zosky
G
George Washko
M
Michael J. Abramson
R
Rosa Faner
A
Alvar Agusti
J
Jennifer Perret
E
E. Haydn Walters
S
Shyamali C. Dharmage *
DOI:10.1002/resp.70279delete
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Abstract

Abstract

En 中文
Identifying impaired lifetime lung function trajectories and their underlying biological pathways is key to characterising the preclinical phase of COPD (Pre-COPD) and its progression. However, this is challenging in practice as repeated spirometry measurements from childhood are rarely available. We investigated potential blood biomarkers associated with pre-COPD trajectories.
Keywords:
biomarker
COPD
lung function trajectory
obstruction
pre-COPD
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Respirology cover
Respirology
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