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Biomimetic nanoplatform potentiates STING-immunotherapy by coordinated delivery of chemotherapeutic and innate immune agonist
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DOI：10.1016/j.matdes.2025.115372.png)
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Abstract
En 中文
• Biomimetic membrane coating confers enhanced tumor targeting and efficient intracellular delivery. • pH-responsive co-release of doxorubicin and a TLR7/8 agonist elicits synergistic tumor cell killing. • Coordinated activation of the cGAS–STING and TLR–MyD88 pathways amplifies type I interferon signaling and antitumor immune responses.
Keywords:
Triple‑negative breast cancer
Cell membrane coating
Tumor microenvironment
Immunogenic cell death
cGAS
Cyclic GMP-AMP synthase
CM
Cell membrane
CRT
Calreticulin
DEGs
Differentially expressed genes
DLC
Drug loading capacity
DOX
Doxorubicin
DR
Free DOX/R848 mixture
DSBs
DNA double-strand breaks
EE
Encapsulation efficiency
GSEA
Gene set enrichment analysis
HMGB1
High mobility group box 1
ICD
Immunogenic cell death
IFN-I
Type I interferons
IVIS
In vivo imaging system
MFI
Mean fluorescence intensity
mIHC
Multiplex immunohistochemistry
NAC
N-acetylcysteine
NPs
Nanoparticles
PDI
Polydispersity index
PLGA
Poly (lactic-co-glycolic acid)
R848
Resiquimod
ROS
Reactive oxygen species
STING
Stimulator of interferon genes
TAMs
Tumor-associated macrophages
TILs
Tumor-infiltrating lymphocytes
TIME
Tumor immune microenvironment
TLR7/8
Toll-like receptor 7/8
TNBC
Triple-negative breast cancer
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