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Biosynthesis of TiO2 nanoparticles via Pleurotus florida as a green nanotechnology-based strategy for multifunctional therapeutic applications
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DOI：10.1515/gps-2025-0093.png)
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Abstract
En 中文
This study presents an environmentally friendly and green approach for the biosynthesis of titanium dioxide nanoparticles (TiO2 NPs) utilizing the Pleurotus florida mushroom extract. The synthesized TiO2 NPs underwent thorough characterization using sophisticated analytical methods. In the ultraviolet-visible spectrum investigation, the absorbance peak was seen at 214 nm, and the XRD findings confirmed that the anatase phase of TiO2 was present. Based on the assessments of cytotoxicity, it was shown that the SK-N-SH cell line, which is the neuroblastoma from humans, exhibited substantial invitro cytotoxicity effects, with an IC50 value of 96.79 mu g/mL. The synthesized nanoparticles displayed significant antibacterial efficacy with the highest significant zone of inhibition reported for Salmonella enterica (16 mm), Proteus vulgaris (15 mm), and Staphylococcus aureus sub sp. (15 mm); the efficacy was against both Gram-positive and Gram-negative bacteria. Furthermore, in vitro antioxidant evaluation confirmed their ability of nanoparticles to scavenge the free radical. At a concentration of 1,000 mu g/mL, the nanoparticles displayed 68.18 % alpha-amylase inhibitory activity, exceeding the standard reference, and demonstrated 86.02 % anti-inflammatory efficacy. This pioneering study underscores the potential of P. florida-mediated TiO2 NPs as multifunctional bioactive agents, paving the way for their application as eco-friendly nanodrugs in biomedical and pharmaceutical domains.
Keywords:
titanium oxide nanoparticles
antioxidants
mushroom
anti-inflammatory
biomedical application
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