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Biotags Based on Surface-Enhanced Raman Can Be as Bright as Fluorescence Tags
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DOI：10.1021/acs.nanolett.5b02594.png)
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Abstract
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Surface enhanced Raman spectroscopy (SERS) is a powerful analytical technique that has been proposed as a substitute for fluorescence for biological imaging and detection but is not yet commercially utilized. The reason lies primarily in the lower intensity and poor reproducibility of most metal nanopartide-based tags as compared to their fluorescence-based counterparts. Here, using a technique that scrupulously preserves the same number of dye molecules in both the SERS and fluorescence measurements, we show that SERS-based biotags (SBTs) with highly reproducible optical properties can be nanoengineered such that their brightness is at least equal to that of fluorescence-based tags.
Keywords:
SERS
fluorescence
detection
imaging silver nanoparticles
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