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Biotransformation Process of Fluoroquinolones by the Ligninolytic Enzymes of Phanerochaete chrysosporium
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DOI：10.1016/j.hazadv.2026.101479.png)
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Abstract
En 中文
• The secretome of Phanerochaete chrysosporium effectively biotransforms the fluoroquinolones levofloxacin and danofloxacin (5–25 mg/L). • LiPs were identified as the key enzymes driving degradation, achieving up to 100% removal under optimized conditions. • Mn²⁺ ions were found to partially inhibit LiP activity. • LC–MS/MS analysis revealed transformation into dealkylated, hydroxylated, and oxidized derivatives. • Toxicity assay indicated that the generated by-products exhibited significantly reduced toxicity compared to the parent antibiotics.
Keywords:
Environmental pollution
Fluoroquinolones
Wastewater treatment
Mycoremediation
Antibiotic biotransformation
Phanerochaete chrysosporium
Fungal peroxydases
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