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Bisphenol F triggers nephrotoxicity: The pivotal role of renal tubular epithelial cells senescence

delete2026-07-24
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OA
AI
K
Keyi Zhang
L
Lin Xiao
Z
Zimin Li
X
Xiaochen Yin
Y
Yujie Duan
H
Hao Li
N
Na Liang
王燕 cover
王燕 (Yan Wang)
Y
Yongchao Su
Z
Zhihao Wei
L
Liangkai Chen
Y
Yuming Hu *
G
Gang Luo *
DOI:10.1016/j.hazadv.2026.101418delete
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Abstract

Abstract

En 中文
• BPF correlates positively with renal dysfunction markers and accelerates renal biological aging in U.S. adults. • BPF is significantly positively correlated with accelerated renal BA and has the highest weight in bisphenol mixtures. • BPF induces dose-dependent renal senescence in rats, exerting stronger effects than equivalent doses of BPA. • BPF primarily induces cellular senescence in RTECs. • The mtDNA/cGAS/STING signaling pathway mediates BPF-induced senescence in human RTECs.
Keywords:
Bisphenols
Biological aging
Renal aging
Renal tubular epithelial cell
NHANES
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Journal

Journal of Hazardous Materials Advances cover
Journal of Hazardous Materials Advances
IF:
7.7
Papers:
1.4K
Citations:
3.1K

Organization

C
central south university
Scholars:
1.7W
Papers: 5.0K
Citations: 3
H
huazhong university of science and technology
Scholars:
2.3W
Papers: 7.2K
Citations: 5
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