.png){kind=icon}
Return
Bisphosphonates decrease telomerase activity and hTERT expression in MCF-7 breast cancer cells
.png){kind=icon}
PRE
AI
DOI：10.1016/j.mce.2005.03.018.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Bisphosphonates are important in the management of tumours with secondary bone involvement. Recent findings have suggested that these drugs also have an effect on primary tumour burden. Telomerase is a cellular ribonucleoprotein reverse transcriptase responsible for elongation of the telomere. Telomerase expression is increased in many cancers. We studied the direct effects of clodronate, alendronate, and pamidronate (from 10(-6) to 10(-4) M) on MCF-7 human breast cancer cell line. In particular, we investigated their effect on viability, proliferation, apoptosis, human telomerase reverse transcriptase expression (h-TERT) activity. Alendronate and pamidronate showed an inhibition of viability (-63 and -35%, respectively; p < 0.0001) and proliferation of cancer cells, while no effect was observed with clodronate. Amino-bisphosphonates induced a significant increase of apoptosis in MCF-7. In addition, they showed a significant decrease in telomerase expression and activity with respect to control and to clodronate. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Keywords:
apoptosis
bisphosphonates
cell proliferation
RT-PCR
telomerase
Journal
IF:
3.6
Papers:
8.1K
Citations:
1.6W
Organization
No organization information available
Cited Papers
Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span.png)
CURRENT BIOLOGY
OAAI
CURRENT BIOLOGYIF7.5
OAAIShareSaveShareSaveShareSave
ShareSaveShareSaveShareSaveShareSaveShareSave
View more