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Bivariate linear mixed models using SAS proc MIXED

delete2002-11-01
delete102
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R
Rodolphe Thiébaut *
H
Hélène Jacqmin‐Gadda
G
Geneviève Chêne
C
Catherine Leport
D
Daniel Commenges
DOI:10.1016/S0169-2607(02)00017-2delete
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Abstract

Abstract

En 中文
Bivariate linear mixed models are useful when analyzing longitudinal data of two associated markers. In this paper, we present a bivariate linear mixed model including random effects or first-order auto-regressive process and independent measurement error for both markers. Codes and tricks to fit these models using SAS Proc MIXED are provided. Limitations of this program are discussed and an example in the field of HIV infection is shown. Despite some limitations, SAS Proc MIXED is a useful tool that may be easily extendable to multivariate response in longitudinal studies. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Keywords:
bivariate random effects model
bivariate first order auto-regressive process
SAS proc MIXED
HIV infection
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Journal

Computer Methods and Programs in Biomedicine cover
Computer Methods and Programs in Biomedicine
IF:
4.8
Papers:
7.0K
Citations:
2.1W

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