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Blimp-1 benefits gut-homing regulatory T cells by maintaining migration/suppressive function in autoimmune diabetes-prone mice
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DOI：10.1016/j.ebiom.2025.106002.png)
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Abstract
En 中文
Genome-wide association studies (GWAS) have shown that Crohn's disease (CD) and type 1 diabetes (T1D) are the top 2 diseases with the highest genetic risk variants and share several susceptible loci. Since both CD and T1D are T cell-mediated diseases, we hypothesise a mechanistic linkage between T-cell homeostasis and a gut–pancreas axis that differentially regulates the immunopathogenesis and development between CD and T1D.
Keywords:
Blimp-1
Gut-homing regulatory T cells
CCR6+RORγt+ Th17-like Treg cells
T-cell receptor signaling strength
Crohn's disease
Type 1 diabetes
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