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Blocking pyruvate carboxylase expression triggers ferroptosis and inhibits non-small cell lung cancer progression
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DOI：10.1016/j.canlet.2026.218764.png)
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Abstract
En 中文
• PC is upregulated in NSCLC and associated with poor prognosis. • PC confers resistance to ferroptosis via AKT-mTOR-mediated FASN/MCAT axis. • DTX1 and USP51 regulate PC stability and modulate ferroptosis. • The combined treatment of DHM with anti-PD-1 enhances antitumor efficacy in NSCLC.
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