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Blood Angiogenesis Markers and Cognition in Older Adults at Risk for Dementia: Marqueurs sanguins de l'angiogenèse et cognition chez les personnes âgées à risque de démence
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DOI：10.1177/07067437251337627.png)
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Abstract
En 中文
Objective Changes in angiogenesis have been shown to contribute to cognitive decline and dementia. We aimed to identify angiogenesis blood markers associated with cognitive performance in older adults with mild cognitive impairment (MCI), remitted major depressive disorder (rMDD), or both (rMDD + MCI) who are at risk for dementia. Method We analyzed data from participants with MCI, rMDD, or rMDD + MCI in the Prevention of Alzheimer's Dementia with Cognitive Remediation plus Transcranial Direct Current Stimulation in Mild Cognitive Impairment and Depression study. Elastic net regression was used to select variables associated with cognitive performance among 19 angiogenesis markers and 6 covariates. Linear regressions were used to determine which of the selected angiogenesis markers were associated with cognitive performance, controlling for the selected covariates. Significant angiogenesis markers were independently analyzed without other angiogenesis markers, controlling for covariates, with subgroup analyses in those with and without rMDD. Results Angiogenin was the only selected marker associated with cognitive performance (beta = 0.28, Padj = 0.03, f(2) = .02) when controlling for other selected markers (endothelial cell-specific molecule 1, e-selectin, interleukin-33 [IL-33], oncostatin M, platelet-derived growth factor-AB, IL-33 receptor, and tissue inhibitor of metalloproteinases-1) and selected covariates (age, education, apolipoprotein E epsilon 4 status, diagnosis, and cardiovascular risk factors). When independently analyzed, angiogenin remained positively associated with cognitive performance (beta = 0.21, P = 0.01, f(2) =.02), controlling for the covariates. In subgroup analyses, angiogenin was also associated with cognition in rMDD and rMDD + MCI participants (beta =0.50, SE = 0.14, P < 0.001, f(2) = 0.08) and in MCI-only participants (beta= 0.20, SE = 0.09, P = 0.02, f(2) = 0.02). Conclusion The association of angiogenin with cognitive performance highlights a potentially novel biological pathway that could influence cognition in older adults at risk for dementia. Angiogenin may protect against cognitive decline, opening new avenues for innovative preventive, or therapeutic interventions. Plain Language SummaryThe relationship between blood markers and thinking/memory in older adults at risk for dementia.This study aimed to identify blood markers related to angiogenesis (the process of new blood vessel formation) that couldpredict cognitive function (memory and thinking abilities), in older adults at risk for dementia. Angiogenesis has been linkedto dementia, and understanding its associated biological factors may help in predicting cognitive decline, particularly in indi-viduals who are at risk for dementia. Participants included adults over 50 years of age with cognitive impairment and/or ahistory of depression. We used the elastic net regression model to select eight out of 19 angiogenesis markers while consid-eringfive out of the six other factors (covariates) that might influence cognition, such as age, education level, apolipoprotein Egenotype, diagnosis, and cardiovascular health. Among the markers studied, angiogenin, a marker that can increase angiogen-esis, stood out as the only one associated with cognitive function. When considering other factors, higher levels of angiogeninwere linked to better cognition. This association was present even when angiogenin was examined on its own, independent ofother angiogenesis markers. Angiogenin might play a protective role in cognition in older adults at risk for dementia. Overall,thefindings highlight angiogenin as a potential biomarker for cognitive health in aging adults, who were at risk with early signsof cognitive impairment and a history of depression. This suggests that angiogenin could be a target for future research intotreatments aimed at preventing or slowing cognitive decline in vulnerable populations.
Keywords:
angiogenesis
angiogenin
cognition
major depressive disorder
mild cognitive impairment
dementia
Mots cl & eacute
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angiogen & egrave
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angiog & eacute
nine
trouble d & eacute
pressif majeur
d & eacute
ficit cognitif l & eacute
ger (DCL)
d & eacute
mence
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