BMI-genome interactions regulate global gene expression with emphasis in brain and gut

2026-06-18

Rebecca Signer

Carina Seah

Hannah Young

Kayla Retallick-Townsley

Julia Ciarcia

Agathe De Pins

Alanna Cote

Seoyeon Lee

Meng Jia

Jessica Johnson

Keira J.A. Johnston

Jiayi Xu

Kristen J. Brennand

Laura M. Huckins *

DOI：10.1016/j.xgen.2026.101280

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Abstract

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• BMI modifies the genetic regulation of gene expression across tissues • Genes regulated by BMI-SNP interactions are enriched for evolutionary importance • Neuronal chromatin at BMI loci responds to inflammatory cytokines in vitro • BMI-SNP interactions improve gene expression prediction and disease gene discovery

Keywords:

eQTLs

BMI

functional genomics

genotype-environment interactions

BMI-genome interactions regulate global gene expression with emphasis in brain and gut

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