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BNCT Multifield Treatment Plan Optimization Based on the Barrier Algorithm
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DOI：10.1080/00295450.2025.2561072.png)
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Abstract
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Boron neutron capture therapy (BNCT) is a selective radiotherapy that causes less harm to healthy tissue than the traditional radiotherapy. However, since the 10B nuclide has a large thermal neutron capture cross section and because of neutron moderation in healthy tissue, an insufficient dose delivery when treating the deep-seated tumor is an obstacle for BNCT. To solve this problem, multifield treatment is used. How to determine the exposure time or the weight for each field to obtain a reasonable dose distribution is also a problem.This paper introduces a method for optimizing angle weights in BNCT multifield treatment plans using the barrier algorithm. To protect the patient and guarantee the treatment effect, the parameters of the optimization consist of gross tumor volume (GTV), organs at risk (OARs), and treatment time limitation. According to the comparison between a single-field plan and an optimized multifield plan, the multifield plan can decrease the side effects of irradiation while ensure GTV receives the prescription dose.In one comparative case (angle23 versus conical2), the maximum dose, mean dose, and equivalent uniform dose of OARs were reduced by approximately 10%. The non-coplanar multifield plan demonstrated an optimal dose distribution in the GTV, as it achieved the prescribed dose while maintaining the best dose homogeneity among all the plans. This optimization can optimize angle weights under the given treatment time limitation to guarantee the feasibility of the treatment plan.
Keywords:
Multifield treatment
barrier algorithm
optimization program
boron neutron capture therapy (BNCT)
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