.png){kind=icon}
.png){kind=icon}
Return
Body roundness index and its association with QUS-defined osteoporosis and bone mineral density in middle-aged and older adults: a cross-sectional analysis
.png){kind=icon}
OA
AI
Y
Q
X
Z
J
B
L
L
J
J
Q
H
DOI：10.3389/fendo.2026.1906809.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
ObjectivesThis study evaluated the association between Body Roundness Index (BRI) and QUS-defined osteoporosis; its discriminative ability; empirical cutoff; and subgroup heterogeneity in middle-aged and older adults.MethodsWe analyzed cross-sectional data from 1; 444 community-dwelling adults aged 35–75 years. Osteoporosis was defined using tibial quantitative ultrasound-derived T-scores. Receiver operating characteristic curves assessed discrimination; restricted cubic splines examined dose-response relationships; logistic and robust regression analyses quantified associations; and subgroup analyses evaluated effect modification.ResultsThe Youden index identified an optimal BRI cutoff of 4.5. High BRI (≥ 4.5) was associated with higher odds of osteoporosis in the unadjusted model (OR = 1.606; 95% CI: 1.292–1.996; P < 0.001); the age- and sex-adjusted model (OR = 1.432; 95% CI: 1.141–1.797; P = 0.002); and the fully adjusted model excluding BMI (OR = 1.404; 95% CI: 1.105–1.783; P = 0.005). The association was approximately linear (P for non-linearity = 0.539; P-overall < 0.001). BRI alone showed modest discrimination (AUC = 0.562; 95% CI: 0.529–0.594); which increased after adjustment for age and sex (AUC = 0.680; 95% CI: 0.652–0.710) and after full covariate adjustment (AUC = 0.695; 95% CI: 0.674–0.731). The association was stronger among participants with metabolic syndrome (OR = 2.62; 95% CI: 1.641–4.179) than among those without it (OR = 1.39; 95% CI: 1.040–1.860; P for interaction = 0.022).ConclusionsHigher BRI was associated with QUS-defined osteoporosis; but BRI alone showed limited discrimination; and the fully adjusted model remained only moderately discriminative. BRI should therefore be considered an adjunctive anthropometric indicator within a broader assessment framework; rather than a stand-alone predictor or screening tool.Clinical trial registrationhttps://www.chictr.org.cn/showproj.html?proj=187762; identifier ChiCTR2300071492.
Keywords:
osteoporosis
risk stratification
cross-sectional study
Body Roundness Index (BRI)
optimal cutoff
Journal
IF:
4.6
Papers:
1.9W
Citations:
6.4W
Organization
Cited Papers