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Botryolides F and G from the Fungus Bartalinia robillardoides with Anthelmintic Activity
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DOI：10.1021/acs.jnatprod.6c00508.png)
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Abstract
En 中文
The chemical investigation of the fungusBartalinia robillardoides CBS 122686 led to the isolation of two new decarestrictines bearing an unusual three-carbon unit appended to the polyketide moiety and named Botryolides F and G. The compounds were structurally characterized, and their absolute configurations were determined through a combination of spectroscopic methods, single-crystal X-ray diffraction, and electronic circular dichroism (ECD) analyses. Botryolide G was assessed for anthelmintic activity and exhibited promising efficacy at a concentration of 100 μg/mL, with no significant cytotoxicity observed.
Keywords:
Circular dichroism spectroscopy
Lactones
Metabolism
Molecular structure
Pharmaceuticals
Journal
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3.6
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1.2W
Citations:
2.9W
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