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Brain-organ Axis: How does stress regulate peripheral immunity through neural signaling?
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DOI：10.1016/j.plrev.2026.04.001.png)
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Abstract
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• The integrative concept of the "brain-organ axis" was first proposed to systematically summarize the manner in which the brain and the peripheral immune system interact under conditions of stress. • The following description provides an overview of the organ-specific branches of neuroimmune regulatory mechanisms in different organs, taking into account their overall characteristics. • A comprehensive summary of the specific mechanisms is provided, accompanied by a series of images that offer a visual representation of the concepts discussed.
Keywords:
Stress
Neuroimmunology
Inflammation
Neuroendocrine
Immune Cells
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