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Branched Polymer-Confined Copper Site for Biomimic Oxidation and Selective Sensing
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DOI：10.1039/D6NJ01014H.png)
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Abstract
En 中文
Artificial oxidases frequently operated through reactive oxygen species (ROS) intermediates. Upon massive leakage from the catalytic site; these ROS may trigger self-quenching; thus affecting the catalytic activity and sensing capability of artificial oxidase. Herein; by mimicking the protein-confined multicopper oxidases; we developed a branched nitrogen-rich polymer to anchor and stabilize proximally distributed CuN4 centers. During biomimetic oxidation; this unique polymer scaffold-anchored proximal Cu sites mediated the oxidase-mimicking catalysis via a 4e-dominated pathway with less release of ROS species while exhibiting the enhanced enzymatic activity compared to most traditional analogues. When applied to the detection of cytotoxic tris(2-carboxyethyl)phosphine; the polymer-confined copper system delivered highly selective response in the presence of various coexisting interferents. Our findings offered a novel approach for developing highly efficient artificial enzyme by designing polymer scaffold to confine multicopper centers; which could act as a powerful platform to reconcile strong biocatalytic capability with oxygen radical control for precision sensing and beyond.
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