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BRCA1 deficiency induces NFκB-dependent type-I interferon signaling in fallopian tube epithelial cells
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DOI：10.1016/j.neo.2026.101320.png)
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Abstract
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• BRCA1 loss in FTE-194 cells increased IRF3 activation and type-I interferon signaling. • BRCA1 loss had little effect on NFκB activation and downstream target genes. • Increased interferon signaling required TBK1, IFNAR and NFκB activation. • BRCA1 loss increased levels of MDA5 and RIG-I but not STING.
Keywords:
Fallopian tube epithelial cells
High-grade serous tubal-ovarian cancer
BRCA1
Cancer predisposition
Inflammatory signaling
Interferon
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