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Breaking the glial loop: astrocytic PAD2 and citrullinated vimentin drive microglial dysfunction in Alzheimer’s disease
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DOI：10.1186/s13024-026-00974-w.png)
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Abstract
En 中文
Zhang et al. reveal that astrocytic PAD2-mediated citrullination of vimentin drives a TLR4-dependent pro-inflammatory loop in microglia, linking glial crosstalk to impaired amyloid clearance and identifying a potential therapeutic and biomarker pathway in Alzheimer’s disease.
Keywords:
Alzheimer’s disease
Astrocytes
Microglia
Glial crosstalk
Protein post-translational modification
Vimentin
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