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Bridging Imaging and Genomics: Domain Knowledge Guided Spatial Transcriptomics Analysis

delete2025-09-16
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OA
AI
W
Wei Zhang
X
Xinci Liu
T
Tong Chen
W
Wenxin Xu
C
Collin Sakal
X
Ximing Nie
王龙 cover
王龙 (Long Wang)
X
Xinyue Li
DOI：10.1016/j.inffus.2025.103746delete
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Abstract

Abstract

En 中文
• Use LLMs and curated summaries to generate informative gene representations. • Leverage vision models to extract multi-scale features from whole slide images. • Propose a multi-modal expert fusion to align gene and image features effectively. • Extensive experiments on three datasets show consistent gains over SOTA methods.
Keywords:
Spatial Transcriptomics
Computational Pathology
Large Language Model
Domain Knowledge
Multimodal Learning
Generative AI
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Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Information Fusion cover
Information Fusion
IF:
15.5
Papers:
4.1K
Citations:
2.7W

Organization

C
Capital Medical University
Scholars:
5.3W
Papers: 3.3W
Citations: 3.2W
C
City University of Hong Kong
Scholars:
2.3W
Papers: 3.0W
Citations: 6.1W
U
university of science and technology beijing
Scholars:
1.1W
Papers: 4.1K
Citations: 2
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