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Broad-host-range Kayvirus phages preferentially infect Staphylocococcus aureus cells with β-glycosylated WTA, the most common bacterial form in the human host
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DOI：10.1016/j.ijantimicag.2026.107755.png)
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Abstract
En 中文
• Myophage phiIPLA-RODI can infect a wide range of Staphylococcus aureus strains from different origins • The degree of phage susceptibility amongst these strains varies greatly, with some isolates requiring a very high MOI • These differences are due to mutations affecting WTA glycosylation and/or capsule production • This phenotype is regulated by the alternative sigma factor SigB and the agr quorum-sensing system
Keywords:
Staphylococcus aureus
phage susceptibility
WTA glycosylation
sigB
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