Bromelain administration improves behavioral functions, reduces astrogliosis and oxidative stress, and increases BDNF expression in adult male rats with REM sleep deprivation

Pouya Baradaran Safa

doi:10.1016/j.tice.2026.103566

Bromelain administration improves behavioral functions, reduces astrogliosis and oxidative stress, and increases BDNF expression in adult male rats with REM sleep deprivation

2026-05-02

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PRE

AI

P

Pouya Baradaran Safa

A

Amirreza Beirami

M

Maral Hasanzadeh

A

Ali Asadi Zeidabadi

S

Sahar Kermani

M

M. Rafiei

F

Fatemeh Zare

A

Abbas Aliaghaei *

M

Meysam Hassani Moghaddam *

M

Mojtaba Sani *

DOI：10.1016/j.tice.2026.103566

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• In REM sleep–deprived rats, treatment with Bromelain. • Improves behavioral performance. • Reduces astrogliosis and astrocyte reactivity in the hippocampus. • Decreases dark neurons and protects hippocampal neurons. • Increases BDNF expression while decreasing REST expression in the hippocampus.

Keywords:

Bromelain

REM sleep deprivation

BDNF

astrogliosis

hippocampus

Bromelain administration improves behavioral functions, reduces astrogliosis and oxidative stress, and increases BDNF expression in adult male rats with REM sleep deprivation

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