C2-Symmetric Chiral Amine Catalysts With N,N'-Axially Chiral Bipyrrole Framework: Design, Synthesis, and Asymmetric Catalytic Applications

Xin Tian

doi:10.1002/chem.71217

C2-Symmetric Chiral Amine Catalysts With N,N'-Axially Chiral Bipyrrole Framework: Design, Synthesis, and Asymmetric Catalytic Applications

2026-05-30

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Xin Tian

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Bin-Miao Yang *

DOI：10.1002/chem.71217

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Abstract

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A concise and stereoselective synthesis of novel C2-symmetric N,N′-axially chiral secondary amine catalysts is presented. Direct chromatographic separation of diastereomeric intermediates on silica gel provided facile access to both atropisomeric forms, enabling subsequent structural and electronic modifications. The utility of these secondary amine catalysts was demonstrated in asymmetric Michael reactions, affording the products in good yields with good to excellent enantioselectivities.

Keywords:

amine catalyst

asymmetric catalysis

bipyrrole

Michael Reaction

N,N-axis

C2-Symmetric Chiral Amine Catalysts With N,N'-Axially Chiral Bipyrrole Framework: Design, Synthesis, and Asymmetric Catalytic Applications

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