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Cadmium(II) imidazole coordination complexes as selective antifungal agents against resistant Candida: Insights into protein binding, electrochemistry, and CYP51 binding predictions
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DOI：10.1016/j.jinorgbio.2026.113391.png)
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Abstract
En 中文
• Cd(II)–imidazole complexes exhibit antifungal activity against fluconazole-resistant C. glabrata isolates. • ITC reveals enthalpy-driven binding of complexes to bovine serum albumin. • Docking indicates CYP51 inhibition and disruption of ergosterol biosynthesis. • Coordination modulates bioactivity while maintaining antifungal selectivity.
Keywords:
Cadmium(II) coordination compounds
Antifungal properties
Selectivity
Intermolecular interactions
Protein binding
Biomolecules
Sterol biosynthesis
Pharmaceuticals
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