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Cadmium reprograms type-I interferon signaling to promote Japanese encephalitis virus infection in neuronal cells

delete2026-07-31
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PRE
AI
Y
Yogita Rawat
V
Vikas Sood *
A
Anuja Krishnan *
M
Mohan Kamthan *
DOI：10.1016/j.lfs.2026.124611delete
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Abstract

Abstract

En 中文
• Cadmium pre-exposure significantly enhances JEV infection in both in vivo and ex vivo models. • Cadmium impairs innate antiviral signaling by disrupting the JAK/STAT axis. • Poly(I:C)-induced antiviral responses are markedly attenuated following cadmium pre-exposure. • Rather than acting on viral particles, cadmium primes host cells into an immunologically permissive state.
Keywords:
Innate immunity
Antiviral
Apoptosis
Interferons
STAT1

Journal

Life Sciences cover
Life Sciences
IF:
5.1
Papers:
1.7W
Citations:
4.7W

Organization

J
jamia hamdard
Scholars:
117
Papers: 42
Citations: 0
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