Caffeic acid reduces Toxoplasma gondii proliferation in human extravillous trophoblast cells (HTR8/SVneo) through induction of pro-inflammatory cytokines and a death process suggestive of apoptosis

2025-11-04

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Yasmin Munhoz dos Santos-Destro

Angélica Paulina Nunes

Raquel Arruda Sanfelice

Virgínia Marcia Concato

Taylon Felipe Silva

Mariana Barbosa Detoni

Danielle Lazarin‐Bidóia

Sara Mayumi Suzuki

Guilherme de Souza

João Luís Garcia

Ivete Conchon‐Costa

Wander Rogério Pavanelli

Eloísa Amália Vieira Ferro

Idessânia Nazareth Costa *

DOI：10.1016/j.micinf.2025.105584

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Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is a public health problem, especially in congenital infections. Current treatments, with spiramycin or pyrimethamine and sulfadiazine, are highly toxic, prompting the search for effective and safe natural alternatives.

Caffeic acid reduces Toxoplasma gondii proliferation in human extravillous trophoblast cells (HTR8/SVneo) through induction of pro-inflammatory cytokines and a death process suggestive of apoptosis

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