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Can CCR2+ non-classical monocytes serve as a diagnostic biomarker in HER2-negative breast cancer? A pilot study
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DOI：10.1016/j.cyto.2026.157170.png)
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Abstract
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• HER2-negative breast cancer induces systemic remodeling of monocyte subsets. • CCR2+ non-classical monocytes increase four-fold in early-stage patients. • The %CCR2+ non-classical subset shows 96% diagnostic sensitivity and specificity. • High diagnostic accuracy is maintained in early disease stages (I–IIB). • CCR2 expression is independent of systemic CCL2 and inflammatory markers.
Keywords:
Monocyte profile
CCR2/CCL2 axis
CCR2+ non-classical monocytes
Breast cancer
Triple negative breast cancer
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