Candidate genetic and multi-omics determinants potentially contributing to Macklin effect development in acute respiratory distress syndrome: A narrative review

2026-06-20

Rosa Paola Radice *

Federica Vignola

Xavier Montagnuolo

Alessandro Belletti

Gianluca Paternoster

Giuseppe Martelli

DOI：10.1016/j.gene.2026.150276

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Abstract

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• This review summarizes candidate molecular determinants of Macklin effect risk. • ARDS-associated genetic variants may contribute to alveolar fragility. • TIMP1, MMP8, PTX3, and CCL2 were recurrently identified across omics studies. • Multi-omics data support molecular stratification of ARDS subphenotypes. • Dedicated prospective studies are required to validate these candidate pathways.

Keywords:

Acute respiratory distress syndrome

Macklin effect

Genetic susceptibility

Molecular biomarkers

Multi-omics integration

Inflammatory pathways

Barotrauma

Candidate genetic and multi-omics determinants potentially contributing to Macklin effect development in acute respiratory distress syndrome: A narrative review

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