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Canned Beans Decrease Serum Total and LDL Cholesterol in Adults with Elevated LDL Cholesterol in a 4-wk Multicenter, Randomized, Crossover Study
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DOI：10.1093/jn/nxab323.png)
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Abstract
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Background: Practical risk reduction strategies are needed to address cardiovascular disease. Beans can decrease LDL cholesterol; however, research into different daily amounts and varieties is warranted. Objectives: To examine the effects of canned beans (daily rotation of black, navy, pinto, dark red kidney, white kidney) in 1-cup (1CB, 180 g) and 1/2-cup (1/2CB, 90 g) daily amounts compared with a 1-cup white rice (WR) control on serum lipid and glycemic biomarkers in adults with elevated LDL cholesterol. Methods: Adults [n = 73, mean +/- SD age: 48.1 +/- 14.2 y; BMI (in kg/m(2)): 25.9 +/- 4.22; fasting serum LDL cholesterol: 3.0-5.0 mmol/L] consumed 1CB, 1/2CB, and WR for 4-wk treatment periods separated by >= 4-wk washouts in a multicenter, randomized, crossover study. Fasting serum LDL cholesterol (primary outcome) and other lipids and glycemic biomarkers (secondary outcomes) were measured on study days 1 and 29 of each treatment period with study day 29 values compared using repeated-measures ANCOVA, including study day 1 values as covariates. Results: Treatment completion was n = 66 for 1CB, n = 68 for 1/2 CB, and n = 64 for WR. Total cholesterol on study day 29 was lower for 1CB (P = 0.04) but not 1/2CB (P = 0.77) compared with WR (-5.46%, -2.74%, -0.65% changes from study day 1, respectively) and did not differ between 1CB and 1/2CB (P = 0.17). LDL cholesterol on study day 29 was also lower for 1CB (P = 0.002) but not 1/2CB (P = 0.30) compared with WR (-8.08%, -3.84%, +0.49% changes from study day 1, respectively) and did not differ between 1CB and 1/2CB (P = 0.11). Other lipids and glycemic biomarkers did not differ among treatments. Conclusions: Consumption of 1 cup (180 g) of canned beans of multiple varieties decreased total and LDL cholesterol in adults with elevated LDL cholesterol, supporting a practical strategy for cardiovascular disease risk reduction.
Keywords:
adults with elevated LDL cholesterol
beans
bean varieties
cardiovascular disease risk
LDL cholesterol
total cholesterol
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