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Capillary muscle
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DOI：10.1073/pnas.1419315112.png)
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Abstract
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The contraction of a muscle generates a force that decreases when increasing the contraction velocity. This hyperbolic force-velocity relationship has been known since the seminal work of A.V. Hill in 1938 [Hill AV (1938) Proc R Soc Lond B Biol Sci 126(843): 136-195]. Hill's heuristic equation is still used, and the sliding-filament theory for the sarcomere [Huxley H, Hanson J (1954) Nature 173 (4412): 973-976; Huxley AF, Niedergerke R (1954) Nature 173 (4412): 971-973] suggested how its different parameters can be related to the molecular origin of the force generator [Huxley AF (1957) Prog Biophys Biophys Chem 7: 255-318; Deshcherevskii VI (1968) Biofizika 13(5): 928-935]. Here, we develop a capillary analog of the sarcomere obeying Hill's equation and discuss its analogy with muscles.
Keywords:
muscle contraction
capillary analog
force-velocity relation
sliding filament
actomyosin cycle
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