.png){kind=icon}
Return
Carbohydrate-Binding Module Tribes
.png){kind=icon}
PRE
AI
DOI：10.1002/bip.22584.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
At present, 69 families of carbohydrate-binding modules (CBMs) have been isolated by statistically significant differences in the amino acid sequences (primary structures) of their members, with most members of different families showing little if any homology. On the other hand, members of the same family have primary and tertiary (three-dimensional) structures that can be computationally aligned, suggesting that they are descended from common protein ancestors. Members of the large majority of CBM families are beta-sandwiches. This raises the question of whether members of different families are descended from distant common ancestors, and therefore are members of the same tribe. We have attacked this problem by attempting to computationally superimpose tertiary structure representatives of each of the 53 CBM families that have members with known tertiary structures. When successful, we have aligned locations of secondary structure elements and determined root mean square deviations and percentages of similarity between adjacent amino acid residues in structures from similar families. Further criteria leading to tribal membership are amino acid chain lengths and bound ligands. These considerations have led us to assign 27 families to nine tribes. Eight of the tribes have members with beta-sandwich structures, while the ninth is composed of structures with beta-trefoils. (C) 2014 Wiley Periodicals, Inc.
Keywords:
carbohydrate-binding module
protein family
protein tribe
secondary structure element
tertiary structure
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
3.2
Papers:
4.2K
Citations:
7.6K
Organization
Cited Papers
ShareSaveShareSaveShareSaveShareSaveA new clan of CBM families based on bioinformatics of starch-binding domains from families CBM20 and CBM21.png)
FEBS JOURNAL
OAAI
FEBS JOURNALIF4.2
OAAIShareSave
View more