Carbon-based catalyst effectively reduces acute and chronic toxicity of metformin ozonation products: Evidence from zebrafish and chemical analysis

Yide He

doi:10.1016/j.seppur.2026.137877

Carbon-based catalyst effectively reduces acute and chronic toxicity of metformin ozonation products: Evidence from zebrafish and chemical analysis

2026-04-06

0

PRE

AI

Y

Yide He

C

Cheng Wang

J

Jing Lu

S

Siyan Fan

R

Ruihao Liu

A

Anlin Xu

S

Sergey A. Sypalov

Y

Yongjun Zhang *

DOI：10.1016/j.seppur.2026.137877

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Abstract

En 中文

• Metformin products from sole and FeMn@AC-catalyzed ozonation at pH 2 and pH 7. • Acute and chronic toxicity of metformin products evaluated with zebrafish. • Biomarkers and genetic data revealing the fundamental toxicity mechanisms. • Chemical composition of metformin TPs elucidated with HPLC-MS. • Calculated toxicity and target-protein binding energy fitting well with experimental results.

Keywords:

metformin

ozonation

carbon-based catalyst

zebrafish

toxicity mechanisms

Carbon-based catalyst effectively reduces acute and chronic toxicity of metformin ozonation products: Evidence from zebrafish and chemical analysis

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