Cardiomyocyte-targeted Gi signaling promotes cardiac repair under sustained adrenergic stress in mice

Marcos Eliezeck

doi:10.1016/j.yjmcc.2026.06.004

Cardiomyocyte-targeted Gi signaling promotes cardiac repair under sustained adrenergic stress in mice

2026-06-05

0

PRE

AI

M

Marcos Eliezeck

S

Sérgio Ricardo Aluotto Scalzo Júnior

M

Mateus Chaves da Costa

V

Victor Moura

T

Thais Marques da Silva

C

Carlos Alberto Aguiar Silva

F

Flavia L. Martins

C

Cibele Rocha-Resende

R

Rubens Fazan

H

Hélio César Salgado

V

Vania F. Prado

A

Adriana C. Girardi

M

Marco Antônio Máximo Prado

S

Silvia Guatimosim *

DOI：10.1016/j.yjmcc.2026.06.004

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Abstract

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• A Myh6-Cre/hM4Di mouse enables selective, time-controlled Gi activation in cardiomyocytes. • Cardiomyocyte Gi activation confers cytoprotection under adrenergic stress. • Gi activation in cardiomyocytes limits CCR2+ monocyte recruitment, with mechanisms yet to be defined. • Cardiomyocyte Gi activation emerges as a targeted strategy to halt adrenergic injury.

Cardiomyocyte-targeted Gi signaling promotes cardiac repair under sustained adrenergic stress in mice

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