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Cardiopedia-Ligand: A ligand-receptor perturbation atlas of human cardiac organoid function and transcriptional state
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DOI：10.1016/j.stem.2026.07.004.png)
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Abstract
En 中文
• Perturbation screen of 87 soluble ligands for function and the transcriptome • Identification of phenotypic, functional, and transcriptional clusters • Identification of divergent transcriptional signatures for inflammatory ligands • Machine learning and ligand fingerprinting identify disease drivers
Keywords:
cardiac organoids
systems biology
organoid screening
transcriptional regulation
pharmacology
heart failure
inflammation
interferons
cell signaling
contraction
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