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Catalytically Triggered and BMSCs-Laden Piezoelectric Injectable Hydrogel for Intervertebral Disc Degeneration Therapy
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DOI：10.1007/s42765-026-00750-x.png)
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Abstract
En 中文
Intervertebral disc degeneration (IDD) is a major cause of low back pain, and injectable hydrogels offer a promising minimally invasive treatment. However, current hydrogels rely on exogenous triggers or have unstable shear-thinning properties, limiting their therapeutic use. We developed a catalytically triggered piezoelectric injectable hydrogel loaded with bone marrow-derived mesenchymal stem cells (BMSCs) for synergistic IDD regeneration. This system uses a gelatin methacryloyl (GelMA) and diacrylate-functionalized Pluronic F-127 (PF127-DA) composite that rapidly crosslinks via a Fenton-like redox reaction between ferrous gluconate and ammonium persulfate, eliminating the need for external triggers. The hydrogel contains poly(L-lactic acid) (PLLA) piezoelectric fibers and BMSCs. Under ultrasound stimulation, PLLA fibers generate piezoelectric microcurrents that stimulate BMSCs, significantly increasing transforming growth factor-beta (TGF-β) secretion. This promotes BMSCs differentiation into nucleus pulposus-like cells and recruits endogenous nucleus pulposus cells, enhancing matrix synthesis. This platform integrates injectable delivery, in situ piezoelectric stimulation, and biological factor regulation, providing a novel and effective strategy for disc regeneration. An injectable piezoelectric hydrogel laden with BMSCs and PLLA short fibers was developed, in which ultrasound-activated piezoelectric currents stimulate TGF-β secretion to direct BMSCs toward nucleus pulposus-like differentiation and enhance matrix synthesis. This integrated approach for IDD treatment thus combines minimally invasive delivery, spatiotemporally precise stimulation and in situ regenerative efficacy.
Keywords:
Intervertebral disc degeneration
Multifunctional hydrogel
Piezoelectric stimulation
Intervertebral disc regeneration
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21.3
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674
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Cited Papers