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CCL28 ameliorates chronic liver damage associated with the recruitment of immunosuppressive IgA antibody-secreting cells in mice
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DOI：10.1016/j.lfs.2026.124615.png)
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Abstract
En 中文
CCL28 functions as a key chemoattractant for IgA antibody-secreting cells (IgA+ ASCs) and is crucial for maintaining mucosal immune defense. Recent research has revealed IgA+ ASCs with immunosuppressive activity in non-mucosal tissues under inflammatory conditions. Here, we explored the contribution of CCL28 to chronic liver damage caused by carbon tetrachloride (CCl4).
Keywords:
ALD
,
alcoholic liver disease
ALT
,
alanine aminotransferase
ASC
,
antibody-secreting cell
CCl4
,
carbon tetrachloride
CTL
,
cytotoxic T lymphocyte
EAE
,
experimental autoimmune encephalomyelitis
ECM
,
extracellular matrix
HCC
,
hepatocellular carcinoma
HSC
,
hepatic stellate cell
KO
,
knockout
MASLD
,
metabolic dysfunction-associated steatotic liver disease
PD-L1
,
programmed death ligand 1
WT
,
wild-type
CCL28
CCR10
IgA
Antibody-secreting cells
IL-10
FasL
Journal
IF:
5.1
Papers:
1.7W
Citations:
4.7W
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