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CD36/ANXA1/TLR4/NF-κB Axis Orchestrates Lipid Metabolism, Chronic Inflammation, and Insulin Resistance in Obese Children

delete2026-05-04
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PRE
AI
Y
Yiqing Yao
W
Weiming Yang
F
Feng Cheng
S
Shunfeng Mao *
DOI：10.1016/j.imlet.2026.107184delete
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Abstract

Abstract

En 中文
• CD36 is strongly upregulated in plasma and adipocytes of obese children. • CD36 promotes adipogenesis via PPARγ and suppresses PI3K/AKT signaling, driving insulin resistance. • CD36 directly binds ANXA1 to activate the TLR4/NF-κB inflammatory pathway. • Blocking TLR4 reverses CD36-induced cytokine release and lipid accumulation. • The CD36/ANXA1/TLR4/NF-κB axis represents a potential therapeutic target in childhood obesity.
Keywords:
CD36
ANXA1
TLR4
NF-κB
insulin resistance

Journal

Immunology Letters cover
Immunology Letters
IF:
2.8
Papers:
4.5K
Citations:
6.1K

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