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Celiac disease plasma cells recognize the active form of transglutaminase 2 with and without bound substrate
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DOI：10.1016/j.jaut.2026.103591.png)
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Abstract
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• Conformational changes in TG2 can mask autoantibody epitopes. • Celiac disease plasma cells preferentially recognize the active enzyme conformation. • Substrate binding to TG2 does not affect plasma cell reactivity. • mAbs from naïve B cells are more conformation sensitive than mAbs from plasma cells.
Keywords:
Autoantibodies
Transglutaminase 2
Celiac disease
Plasma cells
Naïve B cells
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