.png){kind=icon}
.png){kind=icon}
Return
Cell entry by SARS-CoV-2
.png){kind=icon}
OA
AI
DOI：10.1016/j.tibs.2021.06.001.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Severe acute respiratory syndrome virus 2 (SARS-CoV-2) invades host cells by interacting with receptors/coreceptors, as well as with other cofactors, via its spike (S) protein that further mediates fusion between viral and cellular membranes. The host membrane protein, angiotensin-converting enzyme 2 (ACE2), is the major receptor for SARS-CoV-2 and is a crucial determinant for cross-species transmission. In addition, some auxiliary receptors and cofactors are also involved that expand the host/tissue tropism of SARS-CoV-2. After receptor engagement, specific proteases are required that cleave the S protein and trigger its fusogenic activity. Here we discuss the recent advances in understanding the molecular events during SARS-CoV-2 entry which will contribute to developing vaccines and therapeutics.
Keywords:
SPIKE PROTEIN
STRUCTURAL BASIS
CORONAVIRUS
BINDING
VIRUS
ACE2
TRANSMISSION
INFECTION
IDENTIFICATION
GLYCOPROTEIN
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
11
Papers:
6.6K
Citations:
2.0W
Organization
View more organizations