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Cell models for investigating adipocyte differentiation and adipogenesis: a comprehensive updated review
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DOI：10.1016/j.mce.2026.112815.png)
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Abstract
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• Murine cell models ensure reproducibility but show species-specific differences to human models, which better recapitulate obesity-related metabolic dysfunction. • Human cell lines and primary adipose stem and progenitor cells (ASPCs) capture depot- and donor-specific adipose traits. • 3D and co-culture adipose models better reproduce tissue complexity and intercellular crosstalk.
Keywords:
Adipocyte differentiation
Adipogenesis
Cell models
Adipose tissue
3D culture
Co-culture
Human cell lines
Murine models
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