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Cellular Mg2+ decrease causes a distinctive NF-κB-dependent form of cell death
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DOI：10.1016/j.celrep.2026.116964.png)
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Abstract
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• PRL depletion or CNNM expression induces intracellular Mg2+ decrease and massive cell death • Activation of the NF-κB pathway is crucial for Mg2+ decrease-mediated cell death • Dying cells show distinctive features, marked by actin-driven fiber-like protrusions
Keywords:
magnesium
PRL
CNNM
regulated cell death
NF-κB
actin polymerization
CP: cell biology
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