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Cerebral diffusion of posaconazole in an experimental model of disseminated scedosporiosis
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DOI：10.1016/j.biopha.2025.118918.png)
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Abstract
En 中文
• Posaconazole may be used as salvage therapy for cerebral scedosporiosis. • The physicochemical properties of posaconazole suggest low intracerebral diffusion. • The cerebral diffusion of posaconazole is significantly increased in infected rats. • Plasma pharmacokinetics are also affected, especially at late sampling times. • Infection and inflammation should be considered for therapeutic drug monitoring.
Keywords:
Posaconazole
Pharmacokinetics
Experimental scedosporiosis
Inflammation
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B
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7.5
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1.6W
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8.2W
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