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Certolizumab Inhibits Radiographic Progression in Patients with Early Rheumatoid Arthritis and High Rheumatoid Factor Levels: A Pooled, Post‑Hoc Analysis of the Phase 3 C‑EARLY and C‑OPERA Trials
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DOI：10.1016/j.jbspin.2026.106087.png)
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Abstract
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• We conducted post‑hoc analyses on 2 ph3 trials in MTX-naïve patients with early RA • We compared CZP+MTX vs PBO+MTX, stratified by high vs low RF level • Radiographic worsening was low through 52 weeks with CZP+MTX • High RF level did not adversely influence radiographic progression with CZP+MTX • CZP+MTX may be more effective than MTX alone in MTX-naïve patients with early RA
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