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Chain-based precision amplification biosensor for microRNA detection based on dCas13a system and iridium complex
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DOI：10.1016/j.snb.2025.138881.png)
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Abstract
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• An Ir nanocomposite with outstanding photoelectric response performance was constructed. • The dCas13a system was innovatively applied for the first time to simultaneous precise detection of multiple miRNAs. • Signal amplification was achieved by combining Ir nanocomposite with long double-stranded nucleic acid chain. • A chain-based precision amplification biosensor was developed for simultaneous detection of multiple miRNAs.
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